BAG1 anticorps (N-Term)

N° du produit ABIN6990656

L’anticorps Lapin Polyclonal anti-BAG1 a été validé pour WB, ELISA, IF et IHC (p). Il convient pour détecter BAG1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour BAG1 anticorps (N-Term) (ABIN6990656)

Antigène: BAG1 (BCL2-Associated Athanogene (BAG1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BAG1 anticorps

Épitope: N-Term

Purification: BAG-1 Antibody is affinity chromatography purified via peptide column.

Immunogène: BAG-1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human BAG-1. The immunogen is located within the first 50 amino acids of BAG-1.

Isotype: IgG

Information d'application

Indications d'application: BAG-1 antibody can be used for the detection of BAG-1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: BAG-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: BAG-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur BAG1

Antigène: BAG1 (BCL2-Associated Athanogene (BAG1))

Autre désignation: BAG-1

Sujet: BAG-1 Antibody: Bcl-2-associated athanogene 1 (BAG-1) was first identified as an anti-apoptotic bcl-2-binding protein. Later it was found to bind the molecular chaperones Hsp70 and Hsc70 through its carboxy-terminal sequence (termed the Bag domain), resulting in the inhibition of the refolding activity of these chaperones. It is thought that by binding and inhibiting these molecular chaperones, BAG-1is able to modulate the expression level of proteins requiring chaperones to fold correctly. One such group of proteins that are affected is glucocorticoid receptors. Other reports have suggested that the level of BAG-1 expression correlates with the aggressiveness of various cancers. Multiple isoforms of BAG-1 are known to exist.

ID gène: 573

NCBI Accession: NP_004314

UniProt: Q99933